SC 57461

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LTA4 水解酶 (LTA4H) 的有效选择性抑制剂，IC50/Ki 为 5 nM/23 nM；抑制人全血中钙离子载体诱导的 LTB(4) 产生 (IC50=49 nM)。

A potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM; inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM), no effect on production of the cyclooxygenase metabolite thromboxane B(2); orally active in vivo.Irritable Bowel Syndrome Discontinued.

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Animal Model:Fasted CD rats Dosage:0.01, 0.1, 1, and 10 mg/kg Administration:Orally administered Result:The ED50 values were 0.2 mg/kg at 1.0 h and 0.8 mg/kg at 3.0 h. A single dose of 10 mg/kg blocked LTB4 production 79% at 6 h, 67% at 18 h, and 44% at 24 h.

SC 57461A

Others

Other Targets

Other Targets

Other Indications

Irritable Bowel Syndrome

423169-68-0

363.88

C20H25NO3.HCl

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (687.04 mM)

O=C(O)CCN(C)CCCOC1=CC=C(CC2=CC=CC=C2)C=C1

3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride

(-20℃)

With Ice Pack

≥ 2 years